Expression of tumour-specific antigens underlies cancer immunoediting

Competition driven cancer immunoediting

It is a well-established fact that in an actively proliferating state tumors up-regulate glucose consumption to meet increasing energy demands by switching to glycolysis. What is often neglected is that actively proliferating cells of the immune system also switch to glycolysis and thus also have increased energy demands. Moreover, while cancer cells can revert back to aerobic metabolism, rapid...

Immune responses to tumour antigens: implications for antigen specific immunotherapy of cancer.

Tumour associated antigens recognised by cellular or humoral effectors of the immune system are potential targets for antigen specific cancer immunotherapy. Different categories of cancer antigens have been identified that induce cytotoxic T lymphocyte (CTL) responses in vitro and in vivo, namely: (1) "cancer testis" (CT) antigens, expressed in different tumours and normal testis, (2) melanocyt...

CORRELATION BETWEEN EXPRESSION OF CLASS I ANTIGEN AND DEVELOPMENT OF TUMOUR INFILTRATING LYMPHOCYTES (TILS) FROM TUMOUR BIOPSIES OF PATIENTS WITH BLADDER CANCER

This report presents the findings of TIL development from tumour biopsies of patients with bladder cancer. Analysis of tissue sections showed the presence of T cells in intra-epithelial layer in 8 of 12 cases investigated. In a larger group of patients, TILs were established from 7 of 20 cases and expansion of these cells in Interleukin-2 (IL-2) in the presence of conditioned medium (CM) r...

Stage-Specific Expression of Surface Antigens

The immunobiology of cancer immunosurveillance and immunoediting.

The last fifteen years have seen a reemergence of interest in cancer immunosurveillance and a broadening of this concept into one termed cancer immunoediting. The latter, supported by strong experimental data derived from murine tumor models and provocative correlative data obtained by studying human cancer, holds that the immune system not only protects the host against development of primary ...